Advantages of paramagnetic chemical exchange saturation transfer (CEST) complexes having slow to intermediate water exchange properties as responsive MRI agents
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چکیده
منابع مشابه
Responsive paramagnetic chemical exchange saturation transfer MRI contrast agents
Molecular imaging research has shown great potential to assess the molecular compositions of tissues and provide critical information for clinical diagnoses [1]. These noninvasive assessments of molecular compositions may provide earlier diagnoses of pathologies, may predict therapeutic effects before the therapy is initiated and may provide earlier assessments of therapeutic effects soon after...
متن کاملWater saturation shift referencing (WASSR) for chemical exchange saturation transfer (CEST) experiments.
Chemical exchange saturation transfer (CEST) is a contrast mechanism that exploits exchange-based magnetization transfer (MT) between solute and water protons. CEST effects compete with direct water saturation and conventional MT processes, and generally can only be quantified through an asymmetry analysis of the water saturation spectrum (Z-spectrum) with respect to the water frequency, a proc...
متن کاملAnalytical determination of the chemical exchange saturation transfer (CEST) contrast in molecular magnetic resonance imaging
Magnetic resonance based on molecular imaging allows tracing contrast agents thereby facilitating early diagnosis of diseases in a non-invasive fashion that enhances the soft tissue with high spatial resolution. Recently, the exchange of protons between the contrast agent and water, known as the chemical exchange saturation transfer (CEST) effect, has been measured by applying a suitable pulse ...
متن کاملNoninvasive MRI of tissue redox state based on endogenous chemical exchange saturation transfer (CEST) contrast
Target audience: Research scientists or clinicians who are interested in cancer metabolism, oxidative stress and redox state. Introduction/Purpose: Cellular redox state has been demonstrated as a key player in cellular biology. The disturbed balance of the redox state, such as excessive oxidative stress, can lead to many pathologic changes including cancer, heart diseases, neurodegenerative dis...
متن کاملMolecular imaging of tumors and metastases using chemical exchange saturation transfer (CEST) MRI.
The two glucose analogs 2-deoxy-D-glucose (2-DG) and 2-fluoro-2-deoxy-D-glucose (FDG) are preferentially taken up by cancer cells, undergo phosphorylation and accumulate in the cells. Owing to their exchangeable protons on their hydroxyl residues they exhibit significant chemical exchange saturation transfer (CEST) effect in MRI. Here we report CEST-MRI on mice bearing orthotopic mammary tumors...
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ژورنال
عنوان ژورنال: NMR in Biomedicine
سال: 2012
ISSN: 0952-3480
DOI: 10.1002/nbm.2874